Homocysteine thiolactone: metabolic origin and protein homocysteinylation in the human. Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. Calcium export from neurons and multi-kinase signaling cascades contribute to Ouabain neuroprotection in hyperhomocysteinemia. The effect of folinic acid supplementation on homocysteine concentrations in newborns. Hogeveen M, den Heijer M, Schonbeck Y, Ijland M, van Oppenraaij D, Gunnewiek JK, et al. Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status. Hildebrandt W, Sauer R, Bonaterra G, Dugi KA, Edler L, Kinscherf R. Atomic structure and chemistry of human serum albumin. Prevention of neurodevelopmental sequelae of jaundice in the newborn. Homocysteine and disease: causal associations or epiphenomenons? Mol Asp Med. Photo-isomerization and oxidation of bilirubin in mammals is dependent on albumin binding. Goncharova I, Jasprova J, Vitek L, Urbanova M. Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation. Systemic regulation of bilirubin homeostasis: potential benefits of hyperbilirubinemia. 2007 50(2):396–402.įujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M. Homocysteine and nitric oxide are related to blood pressure and vascular function in small-for-gestational-age children. 2010 24(1):53–63.įranco MC, Higa EM, D'Almeida V, de Sousa FG, Sawaya AL, Fortes ZB, et al. Albumin usage in clinical medicine: tradition or therapeutic? Transfus Med Rev. Update on Phototherapy in Jaundiced Neonates. Homocysteine Lowering Trialists’ Collaboration BMJ. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Folic acid attenuates hyperhomocysteinemia-induced glomerular damage in rats. 17(2).Ĭao L, Lou X, Zou Z, Mou N, Wu W, Huang X, et al. 2007 30(1):21–5.īratlid D How bilirubin gets into the brain. Homocysteine: its possible emerging role in at-risk population groups. Transient bilirubin encephalopathy and apnea of prematurity in 28 to 32 weeks gestational age infants. Clinical assessment of bilirubin-induced neurotoxicity in premature infants. Altogether, we highlight a mechanism that FA reduces the plasma Hcy level and thereby enhance the bilirubin-binding ability of albumin, which may provide a novel therapeutic strategy for the treatment of pathological neonatal jaundice. Besides, we demonstrated that the N-Hcy modification of albumin functionally inhibits the bilirubin-binding ability of albumin without altering its protein level both in vitro and in vivo. Furthermore, we identified a novel N-Hcy modification site K 545 of human serum albumin (HSA) using LC-MS/MS, and the mutagenesis assay in HEK293 further validated these observations. Meanwhile, our results also showed that the plasma Hcy level and N-homocysteinylation (N-Hcy) modification of albumin were significantly elevated in the jaundice rats, which were obviously reversed after FA administration. Intriguingly, we found that FA significantly decreased the elevated total bilirubin (TBIL) and direct bilirubin (DBIL) concentration, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activity in PHA- or Hcy-injected rats, indicating that FA improves liver functions. In the present study, we first estimated the protective effects of folic acid (FA) on phenylhydrazine (PHA) or homocysteine (Hcy)-injected neonatal rats (2–3 days aged). However, due to the unclear pathogenesis of pathological neonatal jaundice, effective drugs for this disease remain unsatisfied. In serious cases, pathological neonatal jaundice frequently shows complications including seizures, cerebral palsy, and kernicterus. Neonatal jaundice is a common symptom that occurs in neonates during the first month of their life and is generally divided into physiological and pathological subtypes.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |